STRING 9.05 
  MAPK8 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MAPK8
mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) (427 aa)
(Homo sapiens)
Predicted Functional Partners:
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
     0.999
ATF2
activating transcription factor 2; Transcriptional activator, probably constitutive, which bind [...] (505 aa)
     0.999
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
MAP2K4
mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinas [...] (399 aa)
    0.999
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) gro [...] (711 aa)
     0.998
JUND
jun D proto-oncogene; Binds an AP-1 site and upon cotransfection stimulates the activity of a p [...] (347 aa)
     0.998
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
     0.998
JUNB
jun B proto-oncogene; Transcription factor involved in regulating gene activity following the p [...] (347 aa)
     0.998
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3; The JNK-interacting protein (JIP) gro [...] (1336 aa)
     0.997
DUSP22
dual specificity phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deac [...] (184 aa)
     0.992
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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