STRING 9.05 
  EGLN1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
EGLN1
egl nine homolog 1 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (426 aa)
(Homo sapiens)
Predicted Functional Partners:
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functi [...] (826 aa)
     0.999
EPAS1
endothelial PAS domain protein 1; Transcription factor involved in the induction of oxygen regu [...] (870 aa)
     0.997
OS9
osteosarcoma amplified 9, endoplasmic reticulum lectin; Lectin which functions in endoplasmic r [...] (667 aa)
     0.994
VHL
von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)
     0.993
HIF3A
hypoxia inducible factor 3, alpha subunit; Involved in adaptive response to hypoxia. Suppresses [...] (669 aa)
     0.978
EGLN3
egl nine homolog 3 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (239 aa)
    0.961
ARNT
aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) recept [...] (789 aa)
      0.948
ING4
inhibitor of growth family, member 4; Component of the HBO1 complex which has a histone H4- spe [...] (249 aa)
      0.944
TCEB1
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as [...] (112 aa)
      0.942
TCEB2
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); SIII, also known as [...] (161 aa)
      0.937
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (14%)
Permalink