STRING 9.05 
  PARK2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PARK2
Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May pr [...] (465 aa)
(Homo sapiens)
Predicted Functional Partners:
SNCAIP
synuclein, alpha interacting protein (919 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
UBE2L3
ubiquitin-conjugating enzyme E2L 3; Catalyzes the covalent attachment of ubiquitin to other pro [...] (154 aa)
      0.998
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
     0.998
HSPA4
heat shock 70kDa protein 4 (840 aa)
      0.993
PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiqui [...] (377 aa)
      0.992
SEPT5
septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis [...] (369 aa)
      0.986
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly [...] (320 aa)
      0.981
ATXN3
ataxin 3; Interacts with key regulators (CBP, p300 and PCAF) of transcription and represses tra [...] (361 aa)
      0.976
VHL
von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)
       0.946
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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