STRING 9.05 
  TCF7L2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial ste [...] (596 aa)
(Homo sapiens)
Predicted Functional Partners:
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     0.999
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
     0.993
JUP
junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are ar [...] (745 aa)
     0.973
AXIN2
axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitat [...] (843 aa)
     0.972
CCND1
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition (295 aa)
     0.967
MYC
v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene t [...] (454 aa)
     0.965
TNIK
TRAF2 and NCK interacting kinase; Serine/threonine kinase that acts as an essential activator o [...] (1360 aa)
      0.959
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
      0.943
CTBP1
C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stack [...] (440 aa)
     0.923
NLK
nemo-like kinase; Role in cell fate determination, required for differentiation of bone marrow [...] (527 aa)
     0.922
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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