STRING 9.05 
  HPSE2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
HPSE2
heparanase 2; Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies (592 aa)
(Homo sapiens)
Predicted Functional Partners:
SDC1
syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate a [...] (310 aa)
      0.924
SDC2
syndecan 2; Cell surface proteoglycan that bears heparan sulfate (201 aa)
      0.911
GPC1
glypican 1; Cell surface proteoglycan that bears heparan sulfate (By similarity) (558 aa)
      0.902
HSPG2
heparan sulfate proteoglycan 2; This protein is an integral component of basement membranes. It [...] (4391 aa)
      0.900
AGRN
agrin; Component of the basal lamina that causes the aggregation of acetylcholine receptors and [...] (2045 aa)
       0.899
GPC5
glypican 5; Cell surface proteoglycan that bears heparan sulfate (By similarity) (572 aa)
       0.899
GPC6
glypican 6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface corecep [...] (555 aa)
       0.899
SDC4
syndecan 4; Cell surface proteoglycan that bears heparan sulfate (198 aa)
       0.899
GPC4
glypican 4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the develo [...] (556 aa)
       0.899
GPC3
glypican 3; Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppre [...] (580 aa)
       0.899
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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