STRING 9.05 
  POLH protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
POLH
polymerase (DNA directed), eta; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci (713 aa)
(Homo sapiens)
Predicted Functional Partners:
PCNA
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
     0.999
REV1
REV1 homolog (S. cerevisiae); Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP [...] (1251 aa)
     0.998
UBC
ubiquitin C (685 aa)
      0.994
RAD18
RAD18 homolog (S. cerevisiae); E3 ubiquitin-protein ligase involved in postreplication repair o [...] (495 aa)
      0.993
POLI
polymerase (DNA directed) iota; Error-prone DNA polymerase specifically involved in DNA repair. [...] (740 aa)
     0.871
RCHY1
ring finger and CHY zinc finger domain containing 1; Mediates E3-dependent ubiquitination and p [...] (261 aa)
      0.868
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog); Catalyzes the covalent attachment of ubiquitin [...] (152 aa)
      0.704
POLD1
polymerase (DNA directed), delta 1, catalytic subunit 125kDa; Possesses two enzymatic activitie [...] (1107 aa)
      0.683
REV3L
REV3-like, catalytic subunit of DNA polymerase zeta (yeast) (3130 aa)
       0.669
CADM1
cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manne [...] (442 aa)
       0.657
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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