STRING 9.05 
  MBL2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MBL2
mannose-binding lectin (protein C) 2, soluble (opsonic defect); Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA (248 aa)
(Homo sapiens)
Predicted Functional Partners:
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Fu [...] (728 aa)
     0.998
MASP2
mannan-binding lectin serine peptidase 2; Serum protease that plays an important role in the ac [...] (686 aa)
     0.997
CALR
calreticulin; Molecular calcium binding chaperone promoting folding, oligomeric assembly and qu [...] (417 aa)
      0.962
KRT1
keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin bet [...] (644 aa)
      0.926
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
       0.854
SPG7
spastic paraplegia 7 (pure and complicated autosomal recessive); Putative ATP-dependent proteas [...] (795 aa)
       0.833
CD93
CD93 molecule; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lect [...] (652 aa)
      0.824
BGN
biglycan; May be involved in collagen fiber assembly (By similarity) (368 aa)
       0.804
FCN2
ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immu [...] (313 aa)
       0.784
C1S
complement component 1, s subcomponent; C1s B chain is a serine protease that combines with C1q [...] (688 aa)
       0.752
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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