STRING 9.05 
  TGFBR1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TGFBR1
transforming growth factor, beta receptor 1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta (503 aa)
(Homo sapiens)
Predicted Functional Partners:
SMAD7
SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 r [...] (426 aa)
     0.999
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
     0.999
UBC
ubiquitin C (685 aa)
      0.999
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
     0.999
TGFBR2
transforming growth factor, beta receptor II (70/80kDa); On ligand binding, forms a receptor co [...] (592 aa)
    0.999
TGFB3
transforming growth factor, beta 3; Involved in embryogenesis and cell differentiation (412 aa)
     0.999
SMURF2
SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase which accepts ubiquiti [...] (748 aa)
     0.998
FKBP1A
FK506 binding protein 1A, 12kDa; May play a role in modulation of ryanodine receptor isoform-1 [...] (108 aa)
      0.998
SMURF1
SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquiti [...] (757 aa)
     0.995
SMAD4
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
     0.994
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (20%)
Permalink