STRING 9.05 
  XPA protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
XPA
xeroderma pigmentosum, complementation group A; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (273 aa)
(Homo sapiens)
Predicted Functional Partners:
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes [...] (323 aa)
     0.999
XPC
xeroderma pigmentosum, complementation group C; Involved in DNA excision repair. May play a par [...] (940 aa)
     0.998
RAD23B
RAD23 homolog B (S. cerevisiae); Plays a central role both in proteosomal degradation of misfol [...] (409 aa)
     0.995
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa; Component of the core-TFIIH basal trans [...] (548 aa)
     0.989
RPA2
replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The acti [...] (270 aa)
      0.987
ERCC5
excision repair cross-complementing rodent repair deficiency, complementation group 5; Single-s [...] (1186 aa)
      0.985
ERCC4
excision repair cross-complementing rodent repair deficiency, complementation group 4; Structur [...] (916 aa)
     0.985
ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2; ATP-depe [...] (760 aa)
     0.983
PRKDC
protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)
      0.981
DDB2
damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form th [...] (427 aa)
     0.980
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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