STRING 9.05 
  TLE1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (770 aa)
(Homo sapiens)
Predicted Functional Partners:
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
     0.982
HES6
hairy and enhancer of split 6 (Drosophila); Does not bind DNA itself but suppresses both HES1- [...] (224 aa)
      0.980
FOXG1
forkhead box G1; Transcription repression factor which plays an important role in the establish [...] (489 aa)
      0.976
AES
amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhi [...] (264 aa)
    0.972
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     0.967
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transc [...] (399 aa)
     0.965
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor t [...] (743 aa)
    0.960
HNF1A
HNF1 homeobox A; Required for the expression of several liver specific genes. Binds to the inve [...] (631 aa)
      0.959
HES1
hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a [...] (280 aa)
      0.949
HESX1
HESX homeobox 1; Required for the normal development of the forebrain, eyes and other anterior [...] (185 aa)
      0.945
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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