STRING 9.05 
  PTF1A protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PTF1A
pancreas specific transcription factor, 1a; Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development (328 aa)
(Homo sapiens)
Predicted Functional Partners:
FGF10
fibroblast growth factor 10; Could be a growth factor active in the process of wound healing. A [...] (208 aa)
      0.933
RBPJ
recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulat [...] (500 aa)
      0.931
HNF1B
HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTA [...] (557 aa)
       0.896
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like; Putative transcrip [...] (517 aa)
      0.858
HES1
hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a [...] (280 aa)
       0.738
TCF12
transcription factor 12; Binds specifically to oligomers of E-box motifs. May play important ro [...] (706 aa)
      0.677
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; Catalyzes the phosphorylation of pho [...] (406 aa)
       0.659
CACNB2
calcium channel, voltage-dependent, beta 2 subunit; The beta subunit of voltage-dependent calci [...] (660 aa)
       0.641
PAX4
paired box 4; Plays an important role in the differentiation and development of pancreatic isle [...] (343 aa)
       0.613
ISL1
ISL LIM homeobox 1; Binds to one of the cis-acting domain of the insulin gene enhancer (349 aa)
       0.611
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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