STRING 9.05 
  CUBN protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CUBN
cubilin (intrinsic factor-cobalamin receptor); Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands lik [...] (3623 aa)
(Homo sapiens)
Predicted Functional Partners:
GIF
gastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin co [...] (417 aa)
     0.999
LRP2
low density lipoprotein-related protein 2; Acts together with cubilin to mediate HDL endocytosi [...] (4655 aa)
    0.983
GC
group-specific component (vitamin D binding protein); Multifunctional protein found in plasma, [...] (474 aa)
     0.981
APOA1
apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the li [...] (267 aa)
      0.943
LGMN
legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave asparty [...] (433 aa)
      0.905
ALB
albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2 [...] (609 aa)
      0.784
TF
transferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in [...] (698 aa)
      0.767
CLCN5
chloride channel 5; Proton-coupled chloride transporter. Functions as antiport system and excha [...] (816 aa)
       0.657
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin); Binds phosphatidylcholine, phosphatidylinosit [...] (91 aa)
      0.649
MFI2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; Involved [...] (738 aa)
      0.624
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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