STRING 9.05 
  KL protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
KL
klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1012 aa)
(Homo sapiens)
Predicted Functional Partners:
FGF23
fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phospha [...] (251 aa)
      0.996
GUSB
glucuronidase, beta; Plays an important role in the degradation of dermatan and keratan sulfate [...] (651 aa)
      0.930
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4; UDPGTs are of major importance in the con [...] (528 aa)
      0.902
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3; UDPGT is of major importance in the conju [...] (534 aa)
       0.899
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8; UDPGT is of major importance in the conju [...] (530 aa)
       0.899
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7; UDPGT is of major importance in the conju [...] (530 aa)
       0.899
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5; UDPGT is of major importance in the conju [...] (534 aa)
       0.899
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4; UDPGT is of major importance in the conju [...] (534 aa)
       0.899
ENSG00000215111
Putative uncharacterized protein ENSP00000352989 Fragment (93 aa)
       0.899
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9; UDPGT is of major importance in the conju [...] (530 aa)
       0.899
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (11%)
Permalink