STRING 9.05 
  SRY protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SRY
sex determining region Y; Transcriptional regulator which control a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Facilitates DNA bending. SRY HMG box recognizes DNA by partial int [...] (204 aa)
(Homo sapiens)
Predicted Functional Partners:
WT1
Wilms tumor 1; Transcription factor that plays an important role in cellular development and ce [...] (517 aa)
       0.915
SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Scaffold protein tha [...] (337 aa)
      0.880
GATA4
GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' [...] (442 aa)
       0.874
ICK
intestinal cell (MAK-like) kinase; May play a key role in the development of multiple organ sys [...] (632 aa)
       0.873
FOSL1
FOS-like antigen 1 (271 aa)
       0.829
NTF3
neurotrophin 3; Seems to promotes the survival of visceral and proprioceptive sensory neurons (270 aa)
       0.800
PARP1
poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzi [...] (1014 aa)
       0.800
ETV2
ets variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' ( [...] (370 aa)
       0.800
ZFY
zinc finger protein, Y-linked; Probable transcriptional activator (801 aa)
       0.788
AR
androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that re [...] (920 aa)
      0.781
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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