STRING 9.05 
  SQSTM1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
sequestosome 1; Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels (440 aa)
(Homo sapiens)
Predicted Functional Partners:
ubiquitin C (685 aa)
TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)
microtubule-associated protein 1 light chain 3 alpha; Probably involved in formation of autopha [...] (125 aa)
kelch-like ECH-associated protein 1; Retains NFE2L2/NRF2 in the cytosol. Functions as substrate [...] (624 aa)
protein kinase C, iota; Calcium-independent, phospholipid-dependent, serine- and threonine-spec [...] (596 aa)
protein kinase C, zeta; This is a calcium-independent, phospholipid-dependent, serine- and thre [...] (592 aa)
neighbor of BRCA1 gene 1 (966 aa)
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve gro [...] (796 aa)
ubiquitin B (229 aa)
interleukin-1 receptor-associated kinase 1; Binds to the IL-1 type I receptor following IL-1 en [...] (712 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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