STRING 9.05 
  EWSR1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
EWSR1
Ewing sarcoma breakpoint region 1; Might normally function as a repressor. EWS-fusion- proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (656 aa)
(Homo sapiens)
Predicted Functional Partners:
BARD1
BRCA1 associated RING domain 1; The BRCA1-BARD1 heterodimer coordinates a diverse range of cell [...] (777 aa)
      0.959
CALM1
calmodulin 1 (phosphorylase kinase, delta); Calmodulin mediates the control of a large number o [...] (149 aa)
      0.920
FLI1
Friend leukemia virus integration 1; Sequence-specific transcriptional activator. Recognizes th [...] (452 aa)
      0.912
LMNA
lamin A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic si [...] (664 aa)
       0.854
PRMT8
protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can b [...] (394 aa)
       0.833
PRMT1
protein arginine methyltransferase 1; Methylates (mono and asymmetric dimethylation) the guanid [...] (371 aa)
       0.823
TFIP11
tuftelin interacting protein 11; May play a role in the differentiation of ameloblasts and odon [...] (837 aa)
       0.804
CALM2
calmodulin 2 (phosphorylase kinase, delta) (149 aa)
       0.802
CALM3
calmodulin 3 (phosphorylase kinase, delta) (149 aa)
       0.801
POLR2G
polymerase (RNA) II (DNA directed) polypeptide G; DNA-dependent RNA polymerase catalyzes the tr [...] (172 aa)
      0.746
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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