STRING 9.05 
  ICOSLG protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ICOSLG
inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) (302 aa)
(Homo sapiens)
Predicted Functional Partners:
ICOS
inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namel [...] (199 aa)
     0.989
PTPRC
protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the anti [...] (1304 aa)
       0.827
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b; Cytokine that binds to TNFRSF13B/TACI a [...] (285 aa)
       0.817
PELO
pelota homolog (Drosophila); Required for normal chromosome segregation during cell division an [...] (385 aa)
       0.750
SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Fodrin, which seems to be involved in secre [...] (2477 aa)
       0.659
TMEM38A
transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracel [...] (299 aa)
       0.659
PHB2
prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via [...] (299 aa)
       0.645
ADO
2-aminoethanethiol (cysteamine) dioxygenase (270 aa)
       0.611
MAS1
MAS1 oncogene; Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional [...] (325 aa)
       0.609
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GIT [...] (199 aa)
       0.569
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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