STRING 9.05 
  ICOSLG protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) (302 aa)
(Homo sapiens)
Predicted Functional Partners:
inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namel [...] (199 aa)
protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the anti [...] (1304 aa)
tumor necrosis factor (ligand) superfamily, member 13b; Cytokine that binds to TNFRSF13B/TACI a [...] (285 aa)
pelota homolog (Drosophila); Required for normal chromosome segregation during cell division an [...] (385 aa)
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Fodrin, which seems to be involved in secre [...] (2477 aa)
transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracel [...] (299 aa)
prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via [...] (299 aa)
2-aminoethanethiol (cysteamine) dioxygenase (270 aa)
MAS1 oncogene; Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional [...] (325 aa)
tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GIT [...] (199 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
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