STRING 9.05 
  RELN protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RELN
reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and ApoER2 induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity) (3460 aa)
(Homo sapiens)
Predicted Functional Partners:
VLDLR
very low density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. [...] (873 aa)
     0.999
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface rec [...] (963 aa)
     0.999
DAB1
disabled homolog 1 (Drosophila); Adapter molecule functioning in neural development. May regula [...] (555 aa)
     0.983
PAFAH1B1
platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); Required for proper [...] (410 aa)
     0.980
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 i [...] (1066 aa)
      0.942
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
      0.937
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gat [...] (1484 aa)
      0.933
PAFAH1B3
platelet-activating factor acetylhydrolase, isoform Ib, subunit 3 (29kDa); Inactivates paf by r [...] (231 aa)
      0.933
MAP1B
microtubule-associated protein 1B; The function of brain MAPS is essentially unknown. Phosphory [...] (2468 aa)
      0.927
TBR1
T-box, brain, 1; Probable transcriptional regulator involved in developmental processes. TBR1 i [...] (682 aa)
       0.927
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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