STRING 9.05 
  DAP6 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
DAP6
Death domain-associated protein 6 (Daxx)(hDaxx)(Fas death domain-associated protein)(ETS1-associated protein 1)(EAP1); Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. D [...] (740 aa)
(Homo sapiens)
Predicted Functional Partners:
SUMO1
SUMO1 pseudogene 3; Ubiquitin-like protein which can be covalently attached to target lysines a [...] (101 aa)
      0.955
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor (485 aa)
      0.950
MCRS1
microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting i [...] (475 aa)
      0.949
ATRX
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); Could be [...] (2492 aa)
       0.917
MAP3K5
mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduc [...] (1374 aa)
       0.907
PML
promyelocytic leukemia; Probable transcription factor. May play an important role in recruitmen [...] (882 aa)
      0.904
DEK
DEK oncogene; May have a function in the nucleus (375 aa)
       0.896
CENPC1
centromere protein C 1; Component of the CENPA-NAC (nucleosome-associated) complex, a complex t [...] (943 aa)
       0.896
PAX3
paired box 3; Probable transcription factor associated with development of alveolar rhabdomyosa [...] (505 aa)
       0.894
USP7
ubiquitin specific peptidase 7 (herpes virus-associated); Cleaves ubiquitin fusion protein subs [...] (1102 aa)
       0.894
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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