STRING 9.05 
  CDKN1C protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2); Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life (316 aa)
(Homo sapiens)
Predicted Functional Partners:
CDK4
cyclin-dependent kinase 4; Probably involved in the control of the cell cycle (303 aa)
     0.995
CDK2
cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, [...] (298 aa)
      0.988
SKP2
S-phase kinase-associated protein 2 (p45); Substrate recognition component of a SCF (SKP1-CUL1- [...] (424 aa)
     0.984
CCND1
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition (295 aa)
     0.969
PCNA
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
      0.959
MYOD1
myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibro [...] (320 aa)
      0.949
CDK6
cyclin-dependent kinase 6; Probably involved in the control of the cell cycle. Interacts with D [...] (326 aa)
      0.946
CCNE2
cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase (404 aa)
     0.945
CUL1
cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiqui [...] (776 aa)
     0.943
CCNA2
cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosi [...] (432 aa)
     0.940
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (21%)
Permalink