STRINGSTRING
Nomo1 Nomo1 Ncln Ncln Tmem147 Tmem147 Nepn Nepn Rbm19 Rbm19 Naa38 Naa38 Denr Denr Rrn3 Rrn3 Prr12 Prr12 Abracl Abracl Hint2 Hint2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
Nomo1Nodal modulator 1; May antagonize Nodal signaling. (1214 aa)    
Predicted Functional Partners:
Ncln
Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
   
 
 0.839
Tmem147
Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity).
   
 
 0.611
Nepn
Nephrocan; May inhibit TGF-beta signaling.
      
 0.572
Rbm19
Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development. Belongs to the RRM MRD1 family.
   
  
 0.523
Naa38
N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; Belongs to the snRNP Sm proteins family.
   
  
 0.523
Denr
Density-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity); Belongs to the DENR family.
   
  
 0.512
Rrn3
RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family.
   
  
 0.486
Prr12
Proline-rich protein 12.
   
  
 0.474
Abracl
Costars family protein ABRACL; Belongs to the costars family.
      
 0.449
Hint2
Histidine triad nucleotide-binding protein 2, mitochondrial; Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity); Belongs to the HINT family.
      
 0.445
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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