STRINGSTRING
Tmprss11g Tmprss11g Lrrc66 Lrrc66 Serpinb11 Serpinb11 Cyp3a57 Cyp3a57 Cyp3a59 Cyp3a59 Slc46a2 Slc46a2 Hyal3 Hyal3 Slc13a2 Slc13a2 Krt6a Krt6a Krt6b Krt6b Slc44a3 Slc44a3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmprss11gTransmembrane protease serine 11G non-catalytic chain. (417 aa)    
Predicted Functional Partners:
Lrrc66
Leucine-rich repeat-containing protein 66.
    
 
 0.573
Serpinb11
Serpin B11; Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma.
   
 
 0.515
Cyp3a57
Cytochrome P450, family 3, subfamily a, polypeptide 57.
    
 
 0.499
Cyp3a59
Cytochrome P450, family 3, subfamily a, polypeptide 59.
    
 
 0.467
Slc46a2
Thymic stromal cotransporter protein; May act as a transporter.
   
  
 0.460
Hyal3
Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro [...]
   
 
 0.448
Slc13a2
Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
   
  
 0.423
Krt6a
Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family.
   
   0.417
Krt6b
Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family.
   
   0.408
Slc44a3
Choline transporter-like protein 3.
   
  
 0.401
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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