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Slc4a5 Slc4a5 Dnali1 Dnali1 Prr32 Prr32 Mageb18 Mageb18 Kcne2 Kcne2 Vsig1 Vsig1 Clic6 Clic6 Glb1l2 Glb1l2 Chdh Chdh Slc47a1 Slc47a1 Lrrc23 Lrrc23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Slc4a5Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. (1112 aa)    
Predicted Functional Partners:
Dnali1
Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family.
   
  
 0.638
Prr32
Proline-rich 32.
   
  
 0.613
Mageb18
MAGE family member B18.
      
 0.555
Kcne2
Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...]
   
  
 0.546
Vsig1
V-set and immunoglobulin domain-containing protein 1.
      
 0.543
Clic6
Chloride intracellular channel protein 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
   
  
 0.506
Glb1l2
Beta-galactosidase.
      
 0.501
Chdh
Choline dehydrogenase, mitochondrial; Belongs to the GMC oxidoreductase family.
      
 0.487
Slc47a1
Multidrug and toxin extrusion protein 1; Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Not a transporter for 1-methyl- 4-phenylpyridinium (MPP), procainamide, creatinine, guanidine, p- aminohippurate (PAH) and the anionic cephalosporin cefalozin. MPP- transport activity has been observed in and and may contradict results observed in. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Responsible for the secretion of cationic drugs ac [...]
   
  
 0.476
Lrrc23
Leucine rich repeat containing 23, isoform CRA_a.
      
 0.471
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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