node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acsm1 | Agxt2 | ENSRNOP00000074595 | ENSRNOP00000024035 | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.432 |
Acsm1 | Glyatl2 | ENSRNOP00000074595 | ENSRNOP00000016593 | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.494 |
Acsm1 | Hao2 | ENSRNOP00000074595 | ENSRNOP00000074018 | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. | 0.547 |
Acsm1 | Hgd | ENSRNOP00000074595 | ENSRNOP00000003645 | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | Homogentisate 1, 2-dioxygenase. | 0.405 |
Agxt2 | Acsm1 | ENSRNOP00000024035 | ENSRNOP00000074595 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | 0.432 |
Agxt2 | F13b | ENSRNOP00000024035 | ENSRNOP00000075643 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Coagulation factor XIII B chain. | 0.822 |
Agxt2 | Glyatl2 | ENSRNOP00000024035 | ENSRNOP00000016593 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.457 |
Agxt2 | Hao2 | ENSRNOP00000024035 | ENSRNOP00000074018 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. | 0.895 |
Agxt2 | Hgd | ENSRNOP00000024035 | ENSRNOP00000003645 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Homogentisate 1, 2-dioxygenase. | 0.831 |
Btk | Glyatl2 | ENSRNOP00000071684 | ENSRNOP00000016593 | Tyrosine-protein kinase. | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.556 |
Cyp2b21 | Fmo3 | ENSRNOP00000042986 | ENSRNOP00000004864 | Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.501 |
Cyp2b21 | Glyatl2 | ENSRNOP00000042986 | ENSRNOP00000016593 | Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.531 |
Cyp2b21 | Gsta2 | ENSRNOP00000042986 | ENSRNOP00000043510 | Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. | Glutathione S-transferase alpha-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. | 0.788 |
F13b | Agxt2 | ENSRNOP00000075643 | ENSRNOP00000024035 | Coagulation factor XIII B chain. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.822 |
F13b | Glyatl2 | ENSRNOP00000075643 | ENSRNOP00000016593 | Coagulation factor XIII B chain. | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.860 |
F13b | Hgd | ENSRNOP00000075643 | ENSRNOP00000003645 | Coagulation factor XIII B chain. | Homogentisate 1, 2-dioxygenase. | 0.963 |
Fmo3 | Cyp2b21 | ENSRNOP00000004864 | ENSRNOP00000042986 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. | 0.501 |
Fmo3 | Glyatl2 | ENSRNOP00000004864 | ENSRNOP00000016593 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | 0.445 |
Fmo3 | Hao2 | ENSRNOP00000004864 | ENSRNOP00000074018 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. | 0.533 |
Glyatl2 | Acsm1 | ENSRNOP00000016593 | ENSRNOP00000074595 | Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). | Acyl-coenzyme A synthetase ACSM2, mitochondrial. | 0.494 |