STRINGSTRING
Glyatl2 Glyatl2 F13b F13b Btk Btk Cyp2b21 Cyp2b21 Slc22a25 Slc22a25 Acsm1 Acsm1 Hgd Hgd Hao2 Hao2 Gsta2 Gsta2 Agxt2 Agxt2 Fmo3 Fmo3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Glyatl2Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). (295 aa)    
Predicted Functional Partners:
F13b
Coagulation factor XIII B chain.
   
    0.860
Btk
Tyrosine-protein kinase.
      
 0.556
Cyp2b21
Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family.
   
  
 0.531
Slc22a25
Solute carrier family 22 (Organic anion/cation transporter), member 9.
   
  
 0.519
Acsm1
Acyl-coenzyme A synthetase ACSM2, mitochondrial.
   
  
 0.494
Hgd
Homogentisate 1, 2-dioxygenase.
   
    0.491
Hao2
Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
   
  
 0.490
Gsta2
Glutathione S-transferase alpha-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
   
  
 0.478
Agxt2
Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.457
Fmo3
Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]
   
  
 0.445
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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