node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GNA11 | GNAQ | ENSCPOP00000021515 | ENSCPOP00000026700 | G protein subunit alpha 11. | G protein subunit alpha q. | 0.910 |
GNA11 | Gna15 | ENSCPOP00000021515 | ENSCPOP00000004478 | G protein subunit alpha 11. | Uncharacterized protein. | 0.706 |
GNA11 | HTR1B | ENSCPOP00000021515 | ENSCPOP00000020641 | G protein subunit alpha 11. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.522 |
GNA11 | HTR2A | ENSCPOP00000021515 | ENSCPOP00000032627 | G protein subunit alpha 11. | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 0.949 |
GNA11 | HTR2B | ENSCPOP00000021515 | ENSCPOP00000000383 | G protein subunit alpha 11. | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] | 0.830 |
GNA11 | HTR2C | ENSCPOP00000021515 | ENSCPOP00000030453 | G protein subunit alpha 11. | 5-hydroxytryptamine receptor 2C. | 0.950 |
GNA14 | Gna15 | ENSCPOP00000004849 | ENSCPOP00000004478 | G protein subunit alpha 14. | Uncharacterized protein. | 0.702 |
GNA14 | HTR1B | ENSCPOP00000004849 | ENSCPOP00000020641 | G protein subunit alpha 14. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.522 |
GNA14 | HTR2A | ENSCPOP00000004849 | ENSCPOP00000032627 | G protein subunit alpha 14. | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 0.806 |
GNA14 | HTR2B | ENSCPOP00000004849 | ENSCPOP00000000383 | G protein subunit alpha 14. | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] | 0.798 |
GNA14 | HTR2C | ENSCPOP00000004849 | ENSCPOP00000030453 | G protein subunit alpha 14. | 5-hydroxytryptamine receptor 2C. | 0.809 |
GNAQ | GNA11 | ENSCPOP00000026700 | ENSCPOP00000021515 | G protein subunit alpha q. | G protein subunit alpha 11. | 0.910 |
GNAQ | Gna15 | ENSCPOP00000026700 | ENSCPOP00000004478 | G protein subunit alpha q. | Uncharacterized protein. | 0.704 |
GNAQ | HTR1B | ENSCPOP00000026700 | ENSCPOP00000020641 | G protein subunit alpha q. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.522 |
GNAQ | HTR2A | ENSCPOP00000026700 | ENSCPOP00000032627 | G protein subunit alpha q. | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 0.949 |
GNAQ | HTR2B | ENSCPOP00000026700 | ENSCPOP00000000383 | G protein subunit alpha q. | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] | 0.830 |
GNAQ | HTR2C | ENSCPOP00000026700 | ENSCPOP00000030453 | G protein subunit alpha q. | 5-hydroxytryptamine receptor 2C. | 0.950 |
Gna15 | GNA11 | ENSCPOP00000004478 | ENSCPOP00000021515 | Uncharacterized protein. | G protein subunit alpha 11. | 0.706 |
Gna15 | GNA14 | ENSCPOP00000004478 | ENSCPOP00000004849 | Uncharacterized protein. | G protein subunit alpha 14. | 0.702 |
Gna15 | GNAQ | ENSCPOP00000004478 | ENSCPOP00000026700 | Uncharacterized protein. | G protein subunit alpha q. | 0.704 |