STRINGSTRING
queE queE queC queC PAE2137 PAE2137 PAE0317 PAE0317 guaA guaA PAE0012 PAE0012 folE folE PAE0009 PAE0009 tgtA tgtA moaA moaA nadA nadA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
queECoenzyme PQQ synthesis protein, conjectural; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa)    
Predicted Functional Partners:
queC
Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.995
PAE2137
Hypothetical protein.
  
  
 0.980
PAE0317
GTP cyclohydrolase I, conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
  
  
 0.950
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.807
PAE0012
Conserved hypothetical protein.
       0.793
folE
GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
  
  
 0.758
PAE0009
Hypothetical protein.
       0.693
tgtA
Queuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
   
 0.691
moaA
Molybdenum cofactor biosynthesis protein (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
  
 0.560
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
   
 0.549
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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