node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_0342 | CC_1727 | CC_0342 | CC_1727 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.998 |
CC_0342 | CC_1731 | CC_0342 | CC_1731 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 0.909 |
CC_0342 | CC_3355 | CC_0342 | CC_3355 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 0.965 |
CC_0342 | Kgd | CC_0342 | CC_0339 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 2-oxoglutarate dehydrogenase, E1 component; Identified by match to TIGR protein family HMM TIGR00239. | 0.991 |
CC_0342 | gcvH | CC_0342 | CC_3354 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.978 |
CC_0342 | gcvPA | CC_0342 | CC_3353 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.933 |
CC_0342 | gcvPB | CC_0342 | CC_3352 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.936 |
CC_0342 | glyA | CC_0342 | CC_1357 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
CC_0342 | lipA | CC_0342 | CC_1735 | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Lipoic acid synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.579 |
CC_1727 | CC_0342 | CC_1727 | CC_0342 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 0.998 |
CC_1727 | CC_1731 | CC_1727 | CC_1731 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 0.999 |
CC_1727 | CC_3355 | CC_1727 | CC_3355 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 0.686 |
CC_1727 | Kgd | CC_1727 | CC_0339 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-oxoglutarate dehydrogenase, E1 component; Identified by match to TIGR protein family HMM TIGR00239. | 0.921 |
CC_1727 | gcvH | CC_1727 | CC_3354 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.899 |
CC_1727 | gcvPA | CC_1727 | CC_3353 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.420 |
CC_1727 | lipA | CC_1727 | CC_1735 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Lipoic acid synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.439 |
CC_1727 | lipB | CC_1727 | CC_2176 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.571 |
CC_1731 | CC_0342 | CC_1731 | CC_0342 | Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | 0.909 |
CC_1731 | CC_1727 | CC_1731 | CC_1727 | Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
CC_1731 | CC_3355 | CC_1731 | CC_3355 | Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM. | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 0.961 |