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gcvH gcvH gcvT gcvT gcvP gcvP lpdA lpdA glyA glyA lipA lipA agxT agxT lipB lipB sucA sucA putA-2 putA-2 gltB gltB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
gcvHGlycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)    
Predicted Functional Partners:
gcvT
Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
gcvP
Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 0.999
lpdA
Dihydrolipoamide dehydrogenase LpdA.
 
 
 0.984
glyA
Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.975
lipA
Lipoic acid synthetase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 
 0.928
agxT
Serine-pyruvate aminotransferase AgxT.
    
 0.918
lipB
Lipoyl(octanoyl) transferase LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
  
 0.901
sucA
2-oxoglutarate dehydrogenase complex dehydrogenase E1 component SucA.
   
 
 0.886
putA-2
Bifunctional proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
    
 0.874
gltB
NADPH-dependent glutamate synthase large subunit GltB.
   
 
 0.871
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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