node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
agxT | gcvH | SO_4343 | SO_0780 | Serine-pyruvate aminotransferase AgxT. | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.918 |
agxT | gcvP | SO_4343 | SO_0781 | Serine-pyruvate aminotransferase AgxT. | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.937 |
agxT | gcvT | SO_4343 | SO_0779 | Serine-pyruvate aminotransferase AgxT. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.948 |
agxT | gltB | SO_4343 | SO_1325 | Serine-pyruvate aminotransferase AgxT. | NADPH-dependent glutamate synthase large subunit GltB. | 0.516 |
agxT | glyA | SO_4343 | SO_3471 | Serine-pyruvate aminotransferase AgxT. | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
agxT | lpdA | SO_4343 | SO_0426 | Serine-pyruvate aminotransferase AgxT. | Dihydrolipoamide dehydrogenase LpdA. | 0.904 |
gcvH | agxT | SO_0780 | SO_4343 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine-pyruvate aminotransferase AgxT. | 0.918 |
gcvH | gcvP | SO_0780 | SO_0781 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | SO_0780 | SO_0779 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | gltB | SO_0780 | SO_1325 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | NADPH-dependent glutamate synthase large subunit GltB. | 0.871 |
gcvH | glyA | SO_0780 | SO_3471 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
gcvH | lipA | SO_0780 | SO_1161 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.928 |
gcvH | lipB | SO_0780 | SO_1162 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoyl(octanoyl) transferase LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.901 |
gcvH | lpdA | SO_0780 | SO_0426 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase LpdA. | 0.984 |
gcvH | putA-2 | SO_0780 | SO_3774 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Bifunctional proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.874 |
gcvH | sucA | SO_0780 | SO_1930 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase complex dehydrogenase E1 component SucA. | 0.886 |
gcvP | agxT | SO_0781 | SO_4343 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine-pyruvate aminotransferase AgxT. | 0.937 |
gcvP | gcvH | SO_0781 | SO_0780 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | gcvT | SO_0781 | SO_0779 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvP | gltB | SO_0781 | SO_1325 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | NADPH-dependent glutamate synthase large subunit GltB. | 0.901 |