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kicB kicB kicA kicA mukB mukB smtA smtA matP matP acpP acpP uspA uspA ompC2 ompC2 ompC ompC ompF ompF b4372 b4372
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
kicBPutative killing factor protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (440 aa)    
Predicted Functional Partners:
kicA
Conserved hypothetical protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
 
 
 0.998
mukB
Cell division protein; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.
 
 
 
 0.997
smtA
Putative methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
  
 0.961
matP
Conserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
  
 
 
 0.948
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
   
 
 0.787
uspA
Universal stress protein A; Required for resistance to DNA-damaging agents.
  
     0.757
ompC2
Similar to Salmonella typhi outer membrane protein C precursor OmpC SW:OMPC_SALTI (P09878) (378 aa) fasta scores: E(): 0, 60.4% id in 384 aa, and to Escherichia coli outer membrane protein C precursor OmpC or MeoA or Par SW:OMPC_ECOLI (P06996) (367 aa) fasta scores: E(): 0, 58.9% id in 384 aa; Belongs to the Gram-negative porin family.
  
     0.740
ompC
Similar to Escherichia coli outer membrane protein C precursor OmpC or MeoA or Par SW:OMPC_ECOLI (P06996) (367 aa) fasta scores: E(): 0, 70.3% id in 381 aa, and to Serratia marcescens outer membrane protein C precursor OmpC SW:OMPC_SERMA (Q54471) (376 aa) fasta scores: E(): 0, 68.1% id in 382 aa; Belongs to the Gram-negative porin family.
  
     0.736
ompF
Similar to Klebsiella pneumoniae outer membrane protein C OmpC SW:OMPC_KLEPN (Q48473) (363 aa) fasta scores: E(): 0, 62.2% id in 370 aa, to Escherichia coli outer membrane pore protein E OmpE SW:PHOE_ECOLI (P02932) (351 aa) fasta scores: E(): 0, 58.3% id in 362 aa and to Yersinia pestis YPO1205 (371 aa) fasta scores: E(): 0,62.2% identity in 376 aa overlap; Belongs to the Gram-negative porin family.
  
     0.733
b4372
DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
  
  
 0.721
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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