node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fosB | pksJ | BSU17840 | BSU17180 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.408 |
fosB | pksN | BSU17840 | BSU17210 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.430 |
fosB | yddR | BSU17840 | BSU05080 | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.642 |
lrpA | yddR | BSU05050 | BSU05080 | Transcriptional regulator (Lrp/AsnC family); Negative regulation of glyA transcription and kinB-dependent sporulation. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.424 |
menA | yddR | BSU38490 | BSU05080 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.518 |
msmE | yddR | BSU30270 | BSU05080 | Multiple sugar-binding lipoprotein; Part of the ABC transporter complex MelEDC-MsmX involved in melibiose, raffinose and stachyose import. Binds melibiose, raffinose and stachyose. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.435 |
pksJ | fosB | BSU17180 | BSU17840 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.408 |
pksJ | pksN | BSU17180 | BSU17210 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.999 |
pksJ | yddR | BSU17180 | BSU05080 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.475 |
pksN | fosB | BSU17210 | BSU17840 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.430 |
pksN | pksJ | BSU17210 | BSU17180 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.999 |
pksN | yddR | BSU17210 | BSU05080 | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.462 |
sacB | yddR | BSU34450 | BSU05080 | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.448 |
xre | yddR | BSU12510 | BSU05080 | Phage PBSX transcriptional regulator; Repressor of PBSX. Binds to four sites close to its own gene. Necessary for the maintenance of the lysogenic state. | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 0.681 |
yddR | fosB | BSU05080 | BSU17840 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | Metallothiol transferase; Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. | 0.642 |
yddR | lrpA | BSU05080 | BSU05050 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | Transcriptional regulator (Lrp/AsnC family); Negative regulation of glyA transcription and kinB-dependent sporulation. | 0.424 |
yddR | menA | BSU05080 | BSU38490 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.518 |
yddR | msmE | BSU05080 | BSU30270 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | Multiple sugar-binding lipoprotein; Part of the ABC transporter complex MelEDC-MsmX involved in melibiose, raffinose and stachyose import. Binds melibiose, raffinose and stachyose. | 0.435 |
yddR | pksJ | BSU05080 | BSU17180 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.475 |
yddR | pksN | BSU05080 | BSU17210 | Putative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the UPF0173 family. | Polyketide synthase of type I; Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. | 0.462 |