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cobB cobB NadE NadE nadD nadD deoD deoD nadK nadK pntB pntB TDE_0079 TDE_0079 TDE_2278 TDE_2278 TDE_2279 TDE_2279 TDE_2276 TDE_2276 TDE_0549 TDE_0549
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cobBTranscriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (251 aa)    
Predicted Functional Partners:
NadE
Glutamine-dependent NAD+ synthetase, putative; Identified by similarity to SP:P71911; match to protein family HMM PF02540; Belongs to the NAD synthetase family.
   
 0.956
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.920
deoD
Purine nucleoside phosphorylase; Identified by similarity to SP:O34925; match to protein family HMM PF01048; match to protein family HMM TIGR00107.
    
 0.917
nadK
Inorganic polyphosphate/ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.915
pntB
NAD(P) transhydrogenase, beta subunit; Identified by match to protein family HMM PF02233.
    
  0.901
TDE_0079
Identified by match to protein family HMM PF01381.
 
    0.749
TDE_2278
Hypothetical protein; Identified by Glimmer2; putative.
       0.586
TDE_2279
HD domain protein; Identified by match to protein family HMM PF01966.
       0.586
TDE_2276
Hypothetical protein; Identified by Glimmer2; putative.
       0.562
TDE_0549
TfoX N-terminal domain family protein; Identified by match to protein family HMM PF04993.
    
   0.525
Your Current Organism:
Treponema denticola
NCBI taxonomy Id: 243275
Other names: T. denticola ATCC 35405, Treponema denticola ATCC 35405, Treponema denticola str. ATCC 35405
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