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ilvC ilvC ilvN ilvN ilvD ilvD ilvB ilvB MAP_1532 MAP_1532 ilvB-2 ilvB-2 MAP_1873c MAP_1873c MAP_4208 MAP_4208 MAP_3000c MAP_3000c MAP_3512 MAP_3512 leuB leuB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ilvCIlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)    
Predicted Functional Partners:
ilvN
IlvN.
 
 
 0.999
ilvD
IlvD; Belongs to the IlvD/Edd family.
 
 
 0.998
ilvB
IlvB_1.
 
 
 0.997
MAP_1532
Hypothetical protein.
 
 
 0.980
ilvB-2
IlvB_2; Belongs to the TPP enzyme family.
 
 
 0.979
MAP_1873c
Hypothetical protein; Belongs to the TPP enzyme family.
 
 
 0.978
MAP_4208
Hypothetical protein; Belongs to the TPP enzyme family.
 
 
 0.977
MAP_3000c
Hypothetical protein.
 
 
 0.972
MAP_3512
Hypothetical protein; Belongs to the TPP enzyme family.
 
 
 0.971
leuB
LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
  
 0.967
Your Current Organism:
Mycobacterium avium
NCBI taxonomy Id: 262316
Other names: M. avium subsp. paratuberculosis K-10, Mycobacterium avium subsp. paratuberculosis K-10, Mycobacterium avium subsp. paratuberculosis K10, Mycobacterium avium subsp. paratuberculosis str. K-10, Mycobacterium avium subsp. paratuberculosis strain K-10
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