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pdxT pdxT pdxS pdxS APE_0012 APE_0012 APE_2106.1 APE_2106.1 APE_0317.1 APE_0317.1 APE_0583 APE_0583 APE_0586.1 APE_0586.1 rpiA rpiA prs prs APE_2433.1 APE_2433.1 guaA guaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pdxTPyridoxal 5'-phosphate biosynthesis protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa)    
Predicted Functional Partners:
pdxS
Pyridoxal 5'-phosphate biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
 0.999
APE_0012
ATP-dependent 6-phosphofructokinase; ATP-PFK; Belongs to the carbohydrate kinase PfkB family.
     
 0.829
APE_2106.1
ATP-dependent 6-phosphofructokinase.
     
 0.829
APE_0317.1
Phospho-sugar mutase; Belongs to the phosphohexose mutase family.
     
  0.800
APE_0583
Putative transketolase C-terminal section.
     
  0.800
APE_0586.1
Putative transketolase N-terminal section.
     
  0.800
rpiA
Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
     
  0.800
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
    
  0.800
APE_2433.1
Phospho-sugar mutase; Belongs to the phosphohexose mutase family.
     
  0.800
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
     
 0.588
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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