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purC purC A1E_00145 A1E_00145 glyA-2 glyA-2 A1E_01250 A1E_01250 A1E_01245 A1E_01245 folD folD efp efp A1E_01260 A1E_01260 pyrH pyrH pheT pheT thrS-2 thrS-2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa)    
Predicted Functional Partners:
A1E_00145
Hypothetical protein.
  
    0.846
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.837
A1E_01250
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family.
  
    0.788
A1E_01245
Beta 1,4 glucosyltransferase; COG0463 Glycosyltransferases involved in cell wall biogenesis.
       0.763
folD
Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
    0.533
efp
Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
  
    0.531
A1E_01260
COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase.
       0.450
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.434
pheT
phenylalanyl-tRNA synthetase beta subunit; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
   0.431
thrS-2
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
  
    0.403
Your Current Organism:
Rickettsia canadensis
NCBI taxonomy Id: 293613
Other names: R. canadensis str. McKiel, Rickettsia canadensis str. McKiel, Rickettsia canadensis strain McKiel
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