node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A1C_01290 | folE | A1C_01290 | A1C_02870 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | COG0302 GTP cyclohydrolase I. | 0.995 |
A1C_01290 | queA | A1C_01290 | A1C_01585 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.471 |
A1C_01290 | queC | A1C_01290 | A1C_05455 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | Trans-regulatory protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.971 |
A1C_01290 | queE | A1C_01290 | A1C_04755 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.996 |
A1C_01290 | queF | A1C_01290 | A1C_00555 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.911 |
A1C_01290 | tgt | A1C_01290 | A1C_05610 | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.547 |
A1C_05450 | A1C_05460 | A1C_05450 | A1C_05460 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. | Hypothetical protein. | 0.491 |
A1C_05450 | queC | A1C_05450 | A1C_05455 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. | Trans-regulatory protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.519 |
A1C_05460 | A1C_05450 | A1C_05460 | A1C_05450 | Hypothetical protein. | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. | 0.491 |
A1C_05460 | A1C_05465 | A1C_05460 | A1C_05465 | Hypothetical protein. | Hypothetical protein. | 0.507 |
A1C_05460 | queC | A1C_05460 | A1C_05455 | Hypothetical protein. | Trans-regulatory protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.773 |
A1C_05465 | A1C_05460 | A1C_05465 | A1C_05460 | Hypothetical protein. | Hypothetical protein. | 0.507 |
A1C_05465 | queC | A1C_05465 | A1C_05455 | Hypothetical protein. | Trans-regulatory protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.507 |
folE | A1C_01290 | A1C_02870 | A1C_01290 | COG0302 GTP cyclohydrolase I. | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | 0.995 |
folE | queA | A1C_02870 | A1C_01585 | COG0302 GTP cyclohydrolase I. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.493 |
folE | queC | A1C_02870 | A1C_05455 | COG0302 GTP cyclohydrolase I. | Trans-regulatory protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.563 |
folE | queE | A1C_02870 | A1C_04755 | COG0302 GTP cyclohydrolase I. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.688 |
folE | queF | A1C_02870 | A1C_00555 | COG0302 GTP cyclohydrolase I. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.688 |
folE | tgt | A1C_02870 | A1C_05610 | COG0302 GTP cyclohydrolase I. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.456 |
queA | A1C_01290 | A1C_01585 | A1C_01290 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Hypothetical protein; COG0720 6-pyruvoyl-tetrahydropterin synthase. | 0.471 |