node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_1737 | Sfum_3692 | Sfum_1737 | Sfum_3692 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.856 |
Sfum_1737 | hisA | Sfum_1737 | Sfum_1215 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.862 |
Sfum_1737 | hisB | Sfum_1737 | Sfum_4004 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pca:Pcar_2687 imidazoleglycerol-phosphate dehydratase. | 0.923 |
Sfum_1737 | hisD | Sfum_1737 | Sfum_3299 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.924 |
Sfum_1737 | hisF | Sfum_1737 | Sfum_0483 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.866 |
Sfum_1737 | hisG | Sfum_1737 | Sfum_4055 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.873 |
Sfum_1737 | hisH | Sfum_1737 | Sfum_0484 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.905 |
Sfum_1737 | hisI | Sfum_1737 | Sfum_4056 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.894 |
Sfum_3692 | Sfum_1737 | Sfum_3692 | Sfum_1737 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | 0.856 |
Sfum_3692 | hisA | Sfum_3692 | Sfum_1215 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.990 |
Sfum_3692 | hisB | Sfum_3692 | Sfum_4004 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pca:Pcar_2687 imidazoleglycerol-phosphate dehydratase. | 0.997 |
Sfum_3692 | hisC | Sfum_3692 | Sfum_2015 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: sth:STH2831 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.860 |
Sfum_3692 | hisC-2 | Sfum_3692 | Sfum_2116 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mta:Moth_0515 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.843 |
Sfum_3692 | hisD | Sfum_3692 | Sfum_3299 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.986 |
Sfum_3692 | hisF | Sfum_3692 | Sfum_0483 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.906 |
Sfum_3692 | hisG | Sfum_3692 | Sfum_4055 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.965 |
Sfum_3692 | hisH | Sfum_3692 | Sfum_0484 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
Sfum_3692 | hisI | Sfum_3692 | Sfum_4056 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.996 |
hisA | Sfum_1737 | Sfum_1215 | Sfum_1737 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0487 L-threonine-O-3-phosphate decarboxylase. | 0.862 |
hisA | Sfum_3692 | Sfum_1215 | Sfum_3692 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.990 |