node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_0003 | Hhal_0052 | Hhal_0003 | Hhal_0052 | 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: beta-ketoacyl synthase; KEGG: noc:Noc_1663 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | 0.910 |
Hhal_0003 | bioC | Hhal_0003 | Hhal_0960 | 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: beta-ketoacyl synthase; KEGG: noc:Noc_1663 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.900 |
Hhal_0003 | bioF | Hhal_0003 | Hhal_0962 | 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: beta-ketoacyl synthase; KEGG: noc:Noc_1663 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.673 |
Hhal_0003 | birA | Hhal_0003 | Hhal_0875 | 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: beta-ketoacyl synthase; KEGG: noc:Noc_1663 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.681 |
Hhal_0052 | Hhal_0003 | Hhal_0052 | Hhal_0003 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: beta-ketoacyl synthase; KEGG: noc:Noc_1663 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.910 |
Hhal_0052 | Hhal_0961 | Hhal_0052 | Hhal_0961 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 0.811 |
Hhal_0052 | bioF | Hhal_0052 | Hhal_0962 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.809 |
Hhal_0052 | birA | Hhal_0052 | Hhal_0875 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.841 |
Hhal_0961 | Hhal_0052 | Hhal_0961 | Hhal_0052 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase. | 0.811 |
Hhal_0961 | Hhal_0964 | Hhal_0961 | Hhal_0964 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | KEGG: aeh:Mlg_2437 competence protein F. | 0.700 |
Hhal_0961 | bioA | Hhal_0961 | Hhal_0932 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.419 |
Hhal_0961 | bioB | Hhal_0961 | Hhal_0963 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.866 |
Hhal_0961 | bioC | Hhal_0961 | Hhal_0960 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.977 |
Hhal_0961 | bioD | Hhal_0961 | Hhal_0959 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.944 |
Hhal_0961 | bioF | Hhal_0961 | Hhal_0962 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.992 |
Hhal_0961 | birA | Hhal_0961 | Hhal_0875 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.430 |
Hhal_0964 | Hhal_0961 | Hhal_0964 | Hhal_0961 | KEGG: aeh:Mlg_2437 competence protein F. | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 0.700 |
Hhal_0964 | bioB | Hhal_0964 | Hhal_0963 | KEGG: aeh:Mlg_2437 competence protein F. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.659 |
Hhal_0964 | bioC | Hhal_0964 | Hhal_0960 | KEGG: aeh:Mlg_2437 competence protein F. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.650 |
Hhal_0964 | bioD | Hhal_0964 | Hhal_0959 | KEGG: aeh:Mlg_2437 competence protein F. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.634 |