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tmk tmk thyA thyA Amuc_1970 Amuc_1970 Amuc_0340 Amuc_0340 Amuc_1580 Amuc_1580 Amuc_0922 Amuc_0922 Amuc_1883 Amuc_1883 Amuc_0612 Amuc_0612 Amuc_2178 Amuc_2178 polA polA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.929
Amuc_1970
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.928
Amuc_0340
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: acl:ACL_0821 deoxycytidylate deaminase.
    
 0.923
Amuc_1580
PFAM: nucleoside diphosphate kinase; KEGG: bfs:BF3733 putative nucleoside diphosphate kinase; Belongs to the NDK family.
    
 0.919
Amuc_0922
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC1445 5'-nucleotidase; Belongs to the 5'-nucleotidase family.
  
 
  0.909
Amuc_1883
PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: sru:SRU_1941 Ysh1p: subunit of polyadenylation factor I, putative.
  
    0.788
Amuc_0612
KEGG: sth:STH3256 DNA polymerase III delta' subunit.
  
 
 0.676
Amuc_2178
PFAM: GCN5-related N-acetyltransferase; KEGG: mca:MCA2084 N-acetylglutamate synthase; Belongs to the acetyltransferase family.
 
  
 0.464
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.455
Your Current Organism:
Akkermansia muciniphila
NCBI taxonomy Id: 349741
Other names: A. muciniphila ATCC BAA-835, Akkermansia muciniphila ATCC BAA-835, Akkermansia muciniphila Muc, Akkermansia muciniphila str. ATCC BAA-835, Akkermansia muciniphila strain ATCC BAA-835, Akkermansia sp. Muc
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