STRINGSTRING
hisB hisB hisD hisD ACQ69018.1 ACQ69018.1 hisH hisH hisF hisF ACQ69023.1 ACQ69023.1 ACQ69027.1 ACQ69027.1 hisA hisA hisG hisG ACQ69015.1 ACQ69015.1 hisE hisE
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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textmining
co-expression
protein homology
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hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rpd:RPD_0415 imidazoleglycerol-phosphate dehydratase. (195 aa)    
Predicted Functional Partners:
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
ACQ69018.1
PFAM: aminotransferase class I and II; KEGG: tcx:Tcr_1194 histidinol-phosphate aminotransferase.
 
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.999
ACQ69023.1
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
 
  
 0.999
ACQ69027.1
PFAM: aminotransferase class I and II; KEGG: His8; Histidinol-phosphate aminotransferase, chloroplast precursor, probable; K00817 histidinol-phosphate aminotransferase.
 
 0.998
hisA
TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sat:SYN_00761 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.
 
  
 0.997
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.996
ACQ69015.1
PFAM: tRNA synthetase class II (G H P and S); KEGG: bcb:BCB4264_A1457 ATP phosphoribosyltransferase, regulatory subunit.
 
  
 0.987
hisE
TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; MazG nucleotide pyrophosphohydrolase; KEGG: bsu:BSU34860 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein.
 
  
 0.985
Your Current Organism:
Exiguobacterium sp. AT1b
NCBI taxonomy Id: 360911
Other names: E. sp. AT1b
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