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pyrI pyrI pyrB pyrB pyrC pyrC Tpen_1147 Tpen_1147 pyrD pyrD Tpen_0841 Tpen_0841 Tpen_0081 Tpen_0081 Tpen_0255 Tpen_0255 Tpen_1417 Tpen_1417 Tpen_1664 Tpen_1664 Tpen_1160 Tpen_1160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (159 aa)    
Predicted Functional Partners:
pyrB
TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: ape:APE1663 aspartate carbamoyltransferase catalytic chain.
 0.999
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
    
 0.984
Tpen_1147
TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: mka:MK0735 orotidine-5'-phosphate decarboxylase.
  
  
 0.939
pyrD
Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
  
  
 0.922
Tpen_0841
Asparaginase; PFAM: peptidase T2, asparaginase 2; KEGG: pai:PAE3083 asparaginase.
    
  0.901
Tpen_0081
L-aspartate aminotransferase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aminotransferase, class I and II; KEGG: ape:APE2248 aspartate aminotransferase.
    
  0.900
Tpen_0255
PFAM: aminotransferase, class I and II; KEGG: pai:PAE2251 aspartate aminotransferase (aspC), conjectural.
    
  0.900
Tpen_1417
PFAM: aminotransferase, class I and II; KEGG: ape:APE2248 aspartate aminotransferase.
    
  0.900
Tpen_1664
PFAM: aminotransferase, class I and II; KEGG: ape:APE2248 aspartate aminotransferase.
    
  0.900
Tpen_1160
Dihydroorotate oxidase B, electron transfer subunit; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: mja:MJ1446 dihydroorotate dehydrogenase electron transfer subunit.
  
  
 0.892
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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