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ubiC ubiC ubiA ubiA menF menF AHA_2479 AHA_2479 tyrA tyrA pheA pheA trpE trpE AHA_2924 AHA_2924 AHA_0624 AHA_0624 aspC aspC phhA phhA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ubiCChorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (178 aa)    
Predicted Functional Partners:
ubiA
4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
    
 0.985
menF
Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
     
 0.907
AHA_2479
Isochorismate synthases; Identified by similarity to SP:P10377; match to protein family HMM PF00425; match to protein family HMM TIGR00543.
     
 0.907
tyrA
Chorismate mutase/prephenate dehydrogenase; Identified by match to protein family HMM PF01817; match to protein family HMM PF02153; match to protein family HMM TIGR01799.
    
 0.870
pheA
Chorismate mutase/prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM TIGR01797.
    
 0.869
trpE
Anthranilate synthase component I; Identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00565.
    
 0.822
AHA_2924
Anthranilate synthase component II; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
    
 0.806
AHA_0624
Aromatic-amino-acid aminotransferase; Identified by match to protein family HMM PF00155.
     
 0.803
aspC
Aspartate aminotransferase; Identified by match to protein family HMM PF00155.
     
 0.803
phhA
Phenylalanine-4-hydroxylase; Identified by match to protein family HMM PF00351; match to protein family HMM TIGR01267.
     
  0.800
Your Current Organism:
Aeromonas hydrophila
NCBI taxonomy Id: 380703
Other names: A. hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila str. ATCC 7966, Aeromonas hydrophila subsp. hydrophila strain ATCC 7966
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