STRINGSTRING
alr-3 alr-3 ddl ddl alr-2 alr-2 alr-1 alr-1 ald ald AHA_2473 AHA_2473 murF murF AHA_2627 AHA_2627 dadA dadA murA murA AHA_2887 AHA_2887
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
alr-3Alanine racemase; Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes ten of the 19 natural chiral amino acids known, including both non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Cys, Gln and Asn) and positively charged amino acids (His, Lys and Arg). Is not active on negatively charged (Glu and Asp) or aromatic (Tyr, Trp and Phe) amino acids and displays minimal activity towards beta-branched aliphatic (Ile, Val and Thr) substrates. Enables bacteria to produce and release extracellular non-canonical D-amino acids (NCDAAs) that regulate [...] (408 aa)    
Predicted Functional Partners:
ddl
D-alanine--D-alanine ligase; Cell wall formation.
 
  
 0.951
alr-2
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
  
0.940
alr-1
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. Likely plays an important role in supplying D-alanine, which is an indispensable constituent in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the alanine racemase family.
  
  
 
0.926
ald
Alanine dehydrogenase; Identified by match to protein family HMM PF01262; match to protein family HMM PF01488; match to protein family HMM PF05222; match to protein family HMM TIGR00518; Belongs to the AlaDH/PNT family.
  
 
 0.918
AHA_2473
Dimodular nonribosomal peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM TIGR01733; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 0.904
murF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
   
 0.860
AHA_2627
Aminotransferase, class I and II; Identified by match to protein family HMM PF00155.
    
 0.831
dadA
D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family.
  
  
 0.738
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
 
   
 0.702
AHA_2887
Alanine dehydrogenase/pyridine nucleotide transhydrogenase domain protein; Identified by match to protein family HMM PF01262.
  
  
 0.607
Your Current Organism:
Aeromonas hydrophila
NCBI taxonomy Id: 380703
Other names: A. hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila str. ATCC 7966, Aeromonas hydrophila subsp. hydrophila strain ATCC 7966
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