node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_0416 | Spea_3113 | Spea_0416 | Spea_3113 | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | PFAM: major facilitator superfamily MFS_1; KEGG: slo:Shew_2892 major facilitator superfamily MFS_1. | 0.644 |
Spea_0416 | Spea_3543 | Spea_0416 | Spea_3543 | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | 0.423 |
Spea_0416 | anmK | Spea_0416 | Spea_0993 | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.572 |
Spea_0416 | mpl | Spea_0416 | Spea_0686 | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | UDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.488 |
Spea_0416 | nagZ | Spea_0416 | Spea_1539 | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Glycoside hydrolase family 3 domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.666 |
Spea_0994 | Spea_3543 | Spea_0994 | Spea_3543 | PFAM: peptidase M23B; Opacity-associated protein A domain protein; KEGG: slo:Shew_1021 peptidase M23B. | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | 0.690 |
Spea_0994 | anmK | Spea_0994 | Spea_0993 | PFAM: peptidase M23B; Opacity-associated protein A domain protein; KEGG: slo:Shew_1021 peptidase M23B. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.756 |
Spea_0994 | tyrS | Spea_0994 | Spea_0995 | PFAM: peptidase M23B; Opacity-associated protein A domain protein; KEGG: slo:Shew_1021 peptidase M23B. | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. | 0.605 |
Spea_1162 | anmK | Spea_1162 | Spea_0993 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.464 |
Spea_1162 | mpl | Spea_1162 | Spea_0686 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | UDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.454 |
Spea_3113 | Spea_0416 | Spea_3113 | Spea_0416 | PFAM: major facilitator superfamily MFS_1; KEGG: slo:Shew_2892 major facilitator superfamily MFS_1. | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.644 |
Spea_3113 | anmK | Spea_3113 | Spea_0993 | PFAM: major facilitator superfamily MFS_1; KEGG: slo:Shew_2892 major facilitator superfamily MFS_1. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.420 |
Spea_3113 | nagZ | Spea_3113 | Spea_1539 | PFAM: major facilitator superfamily MFS_1; KEGG: slo:Shew_2892 major facilitator superfamily MFS_1. | Glycoside hydrolase family 3 domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.584 |
Spea_3543 | Spea_0416 | Spea_3543 | Spea_0416 | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.423 |
Spea_3543 | Spea_0994 | Spea_3543 | Spea_0994 | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | PFAM: peptidase M23B; Opacity-associated protein A domain protein; KEGG: slo:Shew_1021 peptidase M23B. | 0.690 |
Spea_3543 | anmK | Spea_3543 | Spea_0993 | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.400 |
Spea_3543 | mpl | Spea_3543 | Spea_0686 | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | UDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.407 |
Spea_3543 | nagZ | Spea_3543 | Spea_1539 | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. | Glycoside hydrolase family 3 domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.432 |
anmK | Spea_0416 | Spea_0993 | Spea_0416 | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: slo:Shew_3434 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.572 |
anmK | Spea_0994 | Spea_0993 | Spea_0994 | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | PFAM: peptidase M23B; Opacity-associated protein A domain protein; KEGG: slo:Shew_1021 peptidase M23B. | 0.756 |