STRINGSTRING
aceK aceK Rpic_2752 Rpic_2752 Rpic_0127 Rpic_0127 Rpic_1232 Rpic_1232 Rpic_0542 Rpic_0542 Rpic_4801 Rpic_4801 Rpic_1236 Rpic_1236 Rpic_0129 Rpic_0129 Rpic_0130 Rpic_0130
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
aceK(Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (611 aa)    
Predicted Functional Partners:
Rpic_2752
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rso:RSc2490 isocitrate dehydrogenase.
 
 
 
 0.909
Rpic_0127
Carbonate dehydratase; PFAM: carbonic anhydrase; KEGG: rso:RSc0277 probable carbonic anhydrase protein.
       0.741
Rpic_1232
TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: rso:RSc1358 isocitrate lyase.
 
  
 0.709
Rpic_0542
PFAM: isocitrate lyase and phosphorylmutase; KEGG: bch:Bcen2424_4447 isocitrate lyase.
  
  
 0.635
Rpic_4801
PFAM: isocitrate lyase and phosphorylmutase; KEGG: bvi:Bcep1808_4997 isocitrate lyase.
  
  
 0.635
Rpic_1236
KEGG: rme:Rmet_1390 malate synthase; TIGRFAM: malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family.
 
  
 0.540
Rpic_0129
PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; KEGG: rso:RSc0279 probable acyl-CoA dehydrogenase oxidoreductase protein.
       0.475
Rpic_0130
Transcriptional regulator, MerR family; PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: rso:RSc0280 putative transcription regulator protein.
 
     0.457
Your Current Organism:
Ralstonia pickettii 12J
NCBI taxonomy Id: 402626
Other names: R. pickettii 12J, Ralstonia pickettii str. 12J, Ralstonia pickettii strain 12J
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