STRINGSTRING
lipB lipB lipA lipA gcvH gcvH acpP acpP Rmag_0541 Rmag_0541 Rmag_0566 Rmag_0566 Rmag_1004 Rmag_1004 Rmag_0654 Rmag_0654 gcvP gcvP Rmag_0962 Rmag_0962 nfuA nfuA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (204 aa)    
Predicted Functional Partners:
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 0.920
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
    
 0.875
Rmag_0541
PFAM: protein of unknown function DUF493; KEGG: neu:NE1487 hypothetical protein; Belongs to the UPF0250 family.
  
  
 0.845
Rmag_0566
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
    
  0.804
Rmag_1004
3-oxoacyl-[acyl-carrier-protein] synthase I; PFAM: beta-ketoacyl synthase; KEGG: tcx:Tcr_1945 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
  0.804
Rmag_0654
Enoyl-[acyl-carrier-protein] reductase (NADH); PFAM: short-chain dehydrogenase/reductase SDR; KEGG: noc:Noc_1769 short-chain dehydrogenase/reductase SDR.
     
  0.800
gcvP
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
 0.554
Rmag_0962
PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: ftl:FTL_0310 pyruvate dehydrogenase, E2 component.
 
 
 0.438
nfuA
Nitrogen-fixing NifU domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
      
 0.422
Your Current Organism:
Ruthia magnifica
NCBI taxonomy Id: 413404
Other names: C. Ruthia magnifica str. Cm (Calyptogena magnifica), Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica), Candidatus Ruthia magnifica strain Cm (Calyptogena magnifica), Ruthia magnifica str. Cm (Calyptogena magnifica)
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