node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Oant_0835 | Oant_0838 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC-2 | Oant_0835 | Oant_3575 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sme:SMa0387 putative HisC3 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.838 |
hisA | hisD | Oant_0835 | Oant_0326 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.958 |
hisA | hisD-2 | Oant_0835 | Oant_3581 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.949 |
hisA | hisE | Oant_0835 | Oant_0833 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bmb:BruAb1_2061 HisE, phosphoribosyl-ATP pyrophosphohydrolase. | 0.998 |
hisA | hisF | Oant_0835 | Oant_0834 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Oant_0835 | Oant_3019 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.992 |
hisA | hisH | Oant_0835 | Oant_0836 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Oant_0835 | Oant_2159 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Oant_0835 | Oant_3018 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.931 |
hisB | hisA | Oant_0838 | Oant_0835 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.998 |
hisB | hisC-2 | Oant_0838 | Oant_3575 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sme:SMa0387 putative HisC3 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | Oant_0838 | Oant_0326 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.987 |
hisB | hisD-2 | Oant_0838 | Oant_3581 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.969 |
hisB | hisE | Oant_0838 | Oant_0833 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bmb:BruAb1_2061 HisE, phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisB | hisF | Oant_0838 | Oant_0834 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Oant_0838 | Oant_3019 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.993 |
hisB | hisH | Oant_0838 | Oant_0836 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Oant_0838 | Oant_2159 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.994 |
hisB | hisZ | Oant_0838 | Oant_3018 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.945 |