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tusD tusD tusC tusC tusB tusB tusA tusA tusE tusE yheO yheO rpsL rpsL fkpA fkpA rpsG rpsG sprT sprT thiI thiI
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tusDSulfurtransferase TusD (tRNA 2-thiouridine synthesizing protein D); Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. (128 aa)    
Predicted Functional Partners:
tusC
tRNA 2-thiouridine synthesizing protein C, protein TusC; silverDB:etchr03157; Belongs to the DsrF/TusC family.
 
 0.999
tusB
tRNA 2-thiouridine synthesizing protein B, protein TusB; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
 
 
 0.996
tusA
Sulfurtransferase (tRNA 2-thiouridine synthesizing protein A); Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the [...]
 
 
 0.989
tusE
Sulfurtransferase (tRNA 2-thiouridine synthesizing protein E); Part of a sulfur-relay system.
 
 
 0.984
yheO
Conserved hypothetical protein YheO; silverDB:etchr03159.
  
    0.885
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
       0.552
fkpA
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (Rotamase); silverDB:etchr03160.
       0.478
rpsG
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
     
 0.434
sprT
Protein of unknown function DUF335; silverDB:etchr02816; Belongs to the SprT family.
  
     0.411
thiI
Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.400
Your Current Organism:
Erwinia tasmaniensis
NCBI taxonomy Id: 465817
Other names: E. tasmaniensis Et1/99, Erwinia tasmaniensis Et1/99, Erwinia tasmaniensis str. Et1/99, Erwinia tasmaniensis strain Et1/99
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