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nudF nudF yqiB yqiB cpdA cpdA nudE nudE prs prs pgm pgm yhfW yhfW deoB deoB nnr nnr yqiA yqiA parE parE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
nudFADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. (209 aa)    
Predicted Functional Partners:
yqiB
DUF1249 protein YqiB; Putative enzyme.
 
    0.980
cpdA
3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP.
 
  
 0.925
nudE
Adenosine nucleotide hydrolase; Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP- ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A); Belongs to the Nudix hydrolase family.
     
 0.920
prs
Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 
 0.906
pgm
Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
   
 
 0.905
yhfW
Phosphopentomutase-related metalloenzyme superfamily protein; Putative mutase.
    
  0.902
deoB
Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
    
  0.902
nnr
Bifunctional NAD(P)H-hydrate repair enzyme; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the N-terminal section; belongs to the NnrE/AIBP family.
  
 0.776
yqiA
Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate.
  
  
 0.753
parE
DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes supercoiled DNA. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. Belongs to the type II topoisomerase family. ParE type 1 subfamily.
       0.637
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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