node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_3025 | PC1_3026 | PC1_3025 | PC1_3026 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | 0.990 |
PC1_3025 | PC1_3030 | PC1_3025 | PC1_3030 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.878 |
PC1_3025 | cyaY | PC1_3025 | PC1_3977 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.658 |
PC1_3025 | hscA | PC1_3025 | PC1_3027 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.948 |
PC1_3025 | hscB | PC1_3025 | PC1_3028 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.966 |
PC1_3025 | iscS | PC1_3025 | PC1_3031 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.833 |
PC1_3025 | nfuA | PC1_3025 | PC1_3926 | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.627 |
PC1_3026 | PC1_3025 | PC1_3026 | PC1_3025 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | 0.990 |
PC1_3026 | PC1_3030 | PC1_3026 | PC1_3030 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.975 |
PC1_3026 | cyaY | PC1_3026 | PC1_3977 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.852 |
PC1_3026 | hscA | PC1_3026 | PC1_3027 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.977 |
PC1_3026 | hscB | PC1_3026 | PC1_3028 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.985 |
PC1_3026 | iscS | PC1_3026 | PC1_3031 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.967 |
PC1_3026 | nfuA | PC1_3026 | PC1_3926 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.488 |
PC1_3030 | PC1_3025 | PC1_3030 | PC1_3025 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | TIGRFAM: FeS assembly protein IscX; PFAM: protein of unknown function DUF528; KEGG: eca:ECA3231 hypothetical protein. | 0.878 |
PC1_3030 | PC1_3026 | PC1_3030 | PC1_3026 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: eca:ECA3232 ferredoxin, 2Fe-2S. | 0.975 |
PC1_3030 | cyaY | PC1_3030 | PC1_3977 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.962 |
PC1_3030 | hscA | PC1_3030 | PC1_3027 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.947 |
PC1_3030 | hscB | PC1_3030 | PC1_3028 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
PC1_3030 | iscS | PC1_3030 | PC1_3031 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.999 |