STRINGSTRING
TK0361 TK0361 rtcB rtcB TK0360 TK0360 TK0359 TK0359 TK0362 TK0362 rtcA rtcA panB panB TK0364 TK0364 prf1 prf1 TK0134 TK0134
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TK0361Hypothetical protein, conserved, DUF101 family; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (142 aa)    
Predicted Functional Partners:
rtcB
RNA terminal phosphate cyclase operon orfB homolog, UPF0027 family; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
 
 0.980
TK0360
tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
     
 0.820
TK0359
Hypothetical protein, conserved.
       0.801
TK0362
Hypothetical protein.
       0.773
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
 
 
 
 0.691
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.679
TK0364
Dolichol-phosphate mannosyltransferase.
  
    0.669
prf1
Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.658
TK0134
Probable acetylpolyamine aminohydrolase, histon deacetylase family.
 
     0.431
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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